I found that the graphics and text were blurry and the mouse controls didn't work properly. Here is the fix I found:
1)Right click on the Machinarium desktop icon (or find the .exe file)
3)Open the Compatibility tab
4)Check the box under settings which says "Disable display scaling on high DPI settings"
The blurriness problem is not unique to Machinarium; I have noticed it in other software as well.
This video covers it well: https://youtu.be/gFcOMjBXPRQ