By "German variant" I'm guessing you mean this
Not knowing German won't be a problem as long as you familiarize yourself with the opening screen (which is the only time text is used to explain what to do during the game).
You can read the English text by playing the Machinairum demo here
. After that first screen there are no more text hints/explanations given. All other hints are provided by the "kill the spiders" mini-game hint feature that only shows visual walkthroughs of each level.
Here is the first "explanation" given at the beginning of the game...
As to your question about whether Windows 10 will play the game, the answer is: yes.
Plug "Can Windows 10 play Windows XP games" into your favorite search engine for the explanation about how to "run a program in compatibility mode".