I think Lamkin has mentioned your solution once before.
Link:
http://machinarium.net/forum/index.php/topic,1380.msg6512.html#msg6512"First thing I'll ask is whether or not you've moved the Machinarium application out of its folder? The Machinarium application must remain in the main Machinarium folder along with the other subfolders '00', '01', '10', and '11'. (If that bothers you, you can always make an alias of the application and move that wherever you wish.)"