Amanita Design's programmer posted
this in the iPAD2 > Machinarium for iPad2 Issues thread: "What about resetting the iPad?..."
And, just before that, JD wrote: "try to restart your iPad: Press and hold the Sleep/Wake button for a few seconds until the red 'slide to power off' slider appears, and then slide the slider. Press and hold the Sleep/Wake button until the Apple logo appears."
I think what the guys are saying here is that, if you want to play Machinarium without hassles you should cold-start your iPAD and go right into the game (no messing around with other Apps first... go right to the game!)